Yearly Archives: 2021

First in human clinical trials of the AnAPN1 malaria transmission-blocking vaccine

  • March 31, 2021
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Former director of the PATH Malaria Vaccine Initiative, Christian Loucq, M.D., says it is exciting to see Dinglasan’s concept moving toward a clinical trial. “There are very interesting issues to be addressed in this project which span the technical, immunological, strategic, regulatory and behavioral,” says Dr. Loucq, who also formerly directed the International Vaccine Institute. […]

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Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

  • January 15, 2021
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Jasmine’s 1st first-author paper (Yay Jasmine!) that dissects very early innate immune defense mechanisms of mosquito vectors following infection with flaviviruses. Inter-host transmission of pathogenic arboviruses such as dengue virus (DENV) and Zika virus (ZIKV) requires systemic infection of the mosquito vector. Successful systemic infection requires initial viral entry and proliferation in the midgut cells […]

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